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In Figure 3, we delineate the hypothetical mechanism of the GHGHRIGF1 axis, which may be mostly mediated by IGF1, on the regulation of mitochondrial biogenesis, mitophagy, and mitochondrial function based on the results of studies in the recent decades

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338,339 In contrast, patients with T1DM often benefit from insulin therapy regarding neuropathic outcomes, as they typically do not exhibit significant insulin resistance

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Pinealon cognitive improvements emerge at one to two weeks, with mood enhancement at four to six weeks